Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

J Mol Med (Berl). 1996 Oct;74(10):589-607. doi: 10.1007/s001090050063.


Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that are activated by dual phosphorylation on threonine and tyrosine residues in response to a wide array of extracellular stimuli. Three distinct groups of MAP kinases have been identified in mammalian cells [extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38]. These MAP kinases are mediators of signal transduction from the cell surface to the nucleus. One nuclear target of these MAP kinase signaling pathways is the transcription factor AP-1. MAP kinases regulate AP-1 transcriptional activity by multiple mechanisms. Here we review recent progress towards understanding AP-1 regulation by the ERK, JNK, and p38 MAP kinase signal transduction pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Humans
  • Mammals
  • Signal Transduction / physiology*
  • Transcription Factor AP-1 / metabolism*


  • Transcription Factor AP-1
  • Calcium-Calmodulin-Dependent Protein Kinases