Effects of inhaled budesonide on allergen-induced airway responses and airway inflammation

Am J Respir Crit Care Med. 1996 Nov;154(5):1267-71. doi: 10.1164/ajrccm.154.5.8912734.


Allergen inhalation by sensitized subjects results in acute bronchoconstriction, which can be followed by a later bronchoconstrictor response, allergen-induced airway hyperresponsiveness, and increases in airway inflammatory cells. Treatment with inhaled glucocorticosteroids attenuates allergen-induced asthmatic airway responses. The purpose of this study was to determine whether a 1-wk pretreatment with inhaled budesonide influences allergen-induced changes in inflammatory cells in blood and induced sputum. Seven subjects with mild atopic asthma were treated in a double-blind, placebo-controlled, randomized, crossover fashion with either inhaled budesonide 400 microg/d, or placebo for 7 d. Allergen challenges were carried out the morning after treatment was discontinued and sputum samples were obtained 7 h after allergen inhalation. Methacholine airway responsiveness was measured, and blood and sputum samples were obtained 24 h post-allergen. Budesonide treatment attenuated the magnitude of both the early and the late asthmatic response, reduced allergen-induced methacholine airway hyperresponsiveness, and attenuated allergen-induced increases in total eosinophils and activated eosinophils. These results suggest that the effects of inhaled glucocorticosteroids on allergen-induced airway responses may be mediated through their inhibition of allergen-induced eosinophil migration and activation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Adult
  • Allergens / adverse effects
  • Allergens / drug effects*
  • Bronchoconstriction / drug effects
  • Bronchoconstrictor Agents / antagonists & inhibitors*
  • Bronchodilator Agents / administration & dosage
  • Bronchodilator Agents / therapeutic use*
  • Budesonide
  • Double-Blind Method
  • Eosinophils / drug effects
  • Female
  • Humans
  • Lung Diseases / chemically induced*
  • Lung Diseases / prevention & control*
  • Male
  • Methacholine Chloride / antagonists & inhibitors*
  • Pregnenediones / administration & dosage
  • Pregnenediones / therapeutic use*


  • Allergens
  • Bronchoconstrictor Agents
  • Bronchodilator Agents
  • Pregnenediones
  • Methacholine Chloride
  • Budesonide