Recurrent ocular toxoplasmosis in patients treated with systemic corticosteroids

Retina. 1996;16(5):383-7. doi: 10.1097/00006982-199616050-00003.


Purpose: The authors discuss a possible relationship between systematic corticosteroid use and reactivation of ocular toxoplasmosis.

Methods: Patients were identified who developed foci of recurrent toxoplasmic retinochoroiditis while being treated with systemic corticosteroids. Case histories were reviewed retrospectively.

Results: During a 10-year interval, three patients were identified at the University of California, Los Angeles, who had been receiving systemic corticosteroid therapy (dose range, 0.27-1.23 mg/kg/day) when they developed recurrent toxoplasmic retinochoroiditis. Disease occurred at intervals of 20 days to approximately 1 year after start of corticosteroid therapy. Lesions were typical in appearance, course, and manner in which they responded to antimicrobial therapy.

Conclusion: Recurrent toxoplasmosis in patients receiving corticosteroid therapy probably is uncommon. These cases do not confirm a causal relationship between corticosteroid use and initiation of disease recurrence.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Animals
  • Anti-Infective Agents / therapeutic use
  • Anti-Inflammatory Agents / adverse effects*
  • Antibodies, Protozoan / analysis
  • Antidotes / therapeutic use
  • Child
  • Chorioretinitis / chemically induced
  • Chorioretinitis / drug therapy
  • Chorioretinitis / parasitology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Leucovorin / therapeutic use
  • Male
  • Middle Aged
  • Prednisolone / adverse effects*
  • Pyrimethamine / therapeutic use
  • Recurrence
  • Sulfadiazine / therapeutic use
  • Toxoplasma / immunology
  • Toxoplasmosis, Ocular / chemically induced*
  • Toxoplasmosis, Ocular / drug therapy
  • Toxoplasmosis, Ocular / physiopathology


  • Anti-Infective Agents
  • Anti-Inflammatory Agents
  • Antibodies, Protozoan
  • Antidotes
  • Sulfadiazine
  • Prednisolone
  • Leucovorin
  • Pyrimethamine