Hyperinsulinemia in the polycystic ovary syndrome: a clinical, endocrine and echographic study in 240 patients

Gynecol Endocrinol. 1996 Oct;10(5):319-26. doi: 10.3109/09513599609012818.

Abstract

In recent years numerous studies have suggested insulin to be an important regulator of ovarian function and hyperinsulinemia to be associated with hyperandrogenism. An oral glucose-tolerance test was carried out in 240 women with polycystic ovary syndrome and, based on its result, 142 of the women (59.2%) were insulin resistant or hyperinsulinemic and 98 (40.8%) were normoinsulinemic. Compared with the normoinsulinemic group, the hyperinsulinemic group had a greater incidence of obesity (52.8 vs. 21.4%), secondary amenorrhea (24.6 vs. 9.2%), androgenic symptoms (85.9 vs. 67.4%) and, in particular, hirsutism with or without acne (71.8 vs. 48.0%). Moreover, the hyperinsulinemic group had significantly higher plasma levels of androstenedione, testosterone, free testosterone and insulin, and lower levels of luteinizing hormone, estradiol and sex hormone-binding globulin.

MeSH terms

  • Adult
  • Amenorrhea / etiology
  • Androstenedione / blood
  • Estradiol / blood
  • Female
  • Glucose Tolerance Test
  • Hirsutism / etiology
  • Humans
  • Hyperandrogenism / complications
  • Hyperinsulinism / complications*
  • Luteinizing Hormone / blood
  • Obesity / complications
  • Polycystic Ovary Syndrome / complications*
  • Sex Hormone-Binding Globulin / metabolism
  • Testosterone / blood

Substances

  • Sex Hormone-Binding Globulin
  • Testosterone
  • Androstenedione
  • Estradiol
  • Luteinizing Hormone