Diverse Molecular Provocation of Programmed Cell Death

Trends Biochem Sci. 1996 Oct;21(10):359-64.

Abstract

The experimental study and manipulation of programmed cell death has been greatly assisted by the identification of genetic and pharmacological tools that can either induce or block cell lethality. This review discusses new insights into the molecular sensing of perturbations induced by such tools, as well as the possible consequences of this detection in determining cell survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amyloid / pharmacology
  • Apoptosis / drug effects
  • Apoptosis / genetics
  • Apoptosis / physiology*
  • Chelating Agents / pharmacology
  • Cytoskeleton / chemistry
  • DNA Damage / genetics
  • Ion Channels / metabolism
  • Oxidants / pharmacology
  • Receptors, Cell Surface / metabolism
  • Signal Transduction / genetics
  • Tumor Necrosis Factor-alpha / pharmacology

Substances

  • Amyloid
  • Chelating Agents
  • Ion Channels
  • Oxidants
  • Receptors, Cell Surface
  • Tumor Necrosis Factor-alpha