Isolation of two cytotoxic diterpenes from the fern Pteris multifida

H J Woerdenbag; L R Lutke; R Bos; J F Stevens; R Hulst; W H Kruizinga; Y P Zhu; E T Elema; H Hendriks; W van Uden; N Pras

doi:10.1515/znc-1996-9-1006

Isolation of two cytotoxic diterpenes from the fern Pteris multifida

Z Naturforsch C J Biosci. 1996 Sep-Oct;51(9-10):635-8. doi: 10.1515/znc-1996-9-1006.

Authors

H J Woerdenbag¹, L R Lutke, R Bos, J F Stevens, R Hulst, W H Kruizinga, Y P Zhu, E T Elema, H Hendriks, W van Uden, N Pras

Affiliation

¹ Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies (GIDS), University of Groningen, The Netherlands.

PMID: 8921632
DOI: 10.1515/znc-1996-9-1006

Abstract

From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, entkaurane-2 beta, 16 alpha-diol and ent-kaur-16-ene-2 beta, 15 alpha-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / toxicity
Carcinoma, Ehrlich Tumor
Cell Division
Cell Survival / drug effects
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / toxicity*
Medicine, Chinese Traditional
Mice
Molecular Structure
Plants, Medicinal*
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Diterpenes