I-123 iodoamphetamine scintigraphic detection of bone metastases from malignant melanoma

Clin Nucl Med. 1996 Nov;21(11):847-50. doi: 10.1097/00003072-199611000-00005.


Widely used for cerebral perfusion imaging, I-123 iodoamphetamine (I-123 IMP) is also known to accumulate in malignant melanomas. A case of malignant melanoma is presented, in which I-123 IMP scintigraphy was useful to visualize the bone metastases. During the period of postoperative follow-up, multiple foci of increased I-123 IMP uptake appeared in the skeleton. Conventional bone scintigraphy was less striking, showing cold defects or irregular radionuclide uptake.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamines*
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / secondary*
  • Humans
  • Iodine Radioisotopes*
  • Male
  • Melanoma / diagnostic imaging*
  • Melanoma / secondary*
  • Middle Aged
  • Radionuclide Imaging


  • Amphetamines
  • Iodine Radioisotopes
  • 4-iodoamphetamine