The nervous system in systemic sclerosis (scleroderma). Clinical features and pathogenetic mechanisms

Rheum Dis Clin North Am. 1996 Nov;22(4):879-92. doi: 10.1016/s0889-857x(05)70306-9.


The involvement of the nervous system in SSc is well recognized today. Different pathogenetic mechanisms are suggested that may alternatively explain the multiform appearance of the clinical spectrum (mononeuritis, mononeuritis multiplex, carpal tunnel syndrome, and so forth). It is now clear that the ANS is the earliest structure targeted by the disease in the gastrointestinal tract. The importance of this observation has not yet been adequately interpreted but may, together with the increasing evidence of the nervous system involvement in SSc, become a leading factor in understanding of the importance of the nervous system in the onset, development, and maintenance of the disease.

Publication types

  • Review

MeSH terms

  • Autonomic Nervous System Diseases / etiology
  • Autonomic Nervous System Diseases / physiopathology
  • Central Nervous System Diseases / etiology
  • Central Nervous System Diseases / physiopathology
  • Humans
  • Nervous System Diseases / etiology*
  • Nervous System Diseases / pathology
  • Nervous System Diseases / physiopathology
  • Peripheral Nervous System Diseases / etiology
  • Peripheral Nervous System Diseases / physiopathology
  • Scleroderma, Systemic / pathology
  • Scleroderma, Systemic / physiopathology*