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. 1995 Dec 1;701(1-2):249-54.
doi: 10.1016/0006-8993(95)01005-5.

Serotonin and 8-OH-DPAT Reduce Excitatory Transmission in Rat Hippocampal Area CA1 via Reduction in Presumed Presynaptic Ca2+ Entry

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Serotonin and 8-OH-DPAT Reduce Excitatory Transmission in Rat Hippocampal Area CA1 via Reduction in Presumed Presynaptic Ca2+ Entry

D Schmitz et al. Brain Res. .

Abstract

The effect of 5-HT and its 1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on excitatory transmission in CA1 pyramidal cells was studied. Using concentrations of 5-HT within a range of 10-50 microM we observed no change in excitatory postsynaptic potentials (EPSPs) in CA1 cells evoked by Schaffer collateral stimulation. However, at higher concentrations, > or = 100 microM, 5-HT caused a significant decrease (30-40%) in EPSP/Cs, an effect that was also mimicked by 50 microM 8-OH-DPAT. A presumed presynaptic Ca2+ entry was measured in stratum radiatum following repetitive stimulation of the Schaffer collaterals with all excitatory synaptic transmission blocked. Both 5-HT and 8-OH-DPAT reduced this Ca2+ entry. These results suggest that 5-HT acts at presynaptic 5-HT1A receptors to reduce Ca2+ entry and thereby glutamatergic synaptic transmission.

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