Cardiac and skeletal muscle scintigraphy in dermato- and polymyositis: clinical implications

Eur J Nucl Med. 1996 Feb;23(2):199-203. doi: 10.1007/BF01731845.


To determine the role of scintigraphy in the detection of skeletal and cardiac involvement in dermato- and polymyositis (DM/PM), we studied 30 patients with a confirmed diagnosis of DM/PM (23 females, 7 males; mean age: 35 years). Technetium-99m pyrophosphate (99mTc-PYP) and gallium-67 scans showed similar sensitivity, specificity and accuracy in the detection of skeletal muscle involvement when compared with serum enzymes (70%, 100% and 80%, respectively). Compared with the clinical parameters, 99mTc-PYP showed 70% and 67Ga 65% accuracy. Abnormal PYP cardiac uptake was observed in 57% of patients, whereas abnormal 67Ga cardiac uptake was seen in only 15%. Electrocardiography was abnormal in 40%, rest gated blood pool study in 23%, and chest X-ray in 13%. In conclusion, both 99mTc-PYP and 67Ga can be useful in the detection of the active phase of muscle disease. However, 99mTc-PYP seems to be more effective than 67Ga in the early diagnosis of cardiac involvement.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Clinical Enzyme Tests
  • Dermatomyositis / diagnosis
  • Dermatomyositis / diagnostic imaging*
  • Electrocardiography
  • Female
  • Gallium Radioisotopes
  • Gated Blood-Pool Imaging
  • Heart / diagnostic imaging*
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal / diagnostic imaging*
  • Polymyositis / diagnosis
  • Polymyositis / diagnostic imaging*
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Technetium Tc 99m Pyrophosphate


  • Gallium Radioisotopes
  • Technetium Tc 99m Pyrophosphate