Puerperal cerebral venous thrombosis associated with decreased free protein S: a case report

J Reprod Med. 1995 Dec;40(12):859-62.


Background: Cerebral venous thrombosis is a rare event with multiple risk factors. This condition can be associated with a hypercoagulable state, such as that seen with dysfunctional or decreased plasma protein C and protein S. Both plasma proteins are naturally occurring, vitamin K-dependent anticoagulants that are important for regulation of the clotting cascade.

Case: A postpartum patient presented with complaints of a severe headache and hypertension and later developed status epilepticus. She was found to have superior sagittal sinus and right internal jugular vein thrombosis and protein S deficiency.

Conclusion: The combination of protein S deficiency and the further reduction due to pregnancy may enhance the risk of major thrombotic episodes in the peripartum period.

MeSH terms

  • Anticoagulants / therapeutic use
  • Female
  • Follow-Up Studies
  • Humans
  • Intracranial Embolism and Thrombosis / diagnosis
  • Intracranial Embolism and Thrombosis / drug therapy
  • Intracranial Embolism and Thrombosis / etiology*
  • Magnetic Resonance Imaging
  • Pregnancy
  • Protein S Deficiency / blood
  • Protein S Deficiency / complications*
  • Puerperal Disorders / diagnosis
  • Puerperal Disorders / drug therapy
  • Puerperal Disorders / etiology*
  • Risk Factors


  • Anticoagulants