Human lens epithelial cells proliferate in response to exogenous EGF and have EGF and EGF receptor

Ophthalmic Res. 1995;27(6):356-65. doi: 10.1159/000267748.


While epidermal growth factor (EGF) has been found to exist in the human aqueous humor, which is necessary for maintaining the physiological condition of the lens, our immunohistochemical study confirmed the presence of EGF receptors and EGF in human lens epithelial cells (LECs), with EGF promoting growth potential and morphological change of the cells. Based on these findings, we feel that the effect of EGF upon human LECs is related to the movement of the cells in vivo.

MeSH terms

  • Aged
  • Cell Division / drug effects
  • Cells, Cultured
  • Epidermal Growth Factor / analysis*
  • Epidermal Growth Factor / pharmacology*
  • Epithelial Cells
  • Epithelium / chemistry
  • Epithelium / drug effects
  • ErbB Receptors / analysis*
  • Humans
  • Lens, Crystalline / chemistry
  • Lens, Crystalline / cytology*
  • Lens, Crystalline / drug effects*
  • Middle Aged


  • Epidermal Growth Factor
  • ErbB Receptors