p53 protein expression in esophageal squamous cell papillomas: a study of 36 lesions

Scand J Gastroenterol. 1996 Jan;31(1):10-3. doi: 10.3109/00365529609031620.


Background and methods: In the present study 36 esophageal squamous cell papillomas (ESCP), uncommon benign neoplasms of the esophagus, were investigated retrospectively for p53 immunoreactivity by using the monoclonal antibody PAb 1801. Two ESCPs had previously been found to be human papillomavirus (HPV) type-6-positive.

Results: Only very occasional epithelial cells were stained in two cases, and in three ESCPs p53 staining was restricted to the basal epithelial cells. Both HPV-positive ESCPs remained p53-negative.

Conclusion: We speculate that these findings are the result of immunohistochemical detection of the stabilized wild-type p53 protein rather then mutated p53 protein.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Esophageal Neoplasms / chemistry*
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / virology
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Papilloma / chemistry*
  • Papilloma / pathology
  • Papilloma / virology
  • Papillomaviridae
  • Prevalence
  • Retrospective Studies
  • Tumor Suppressor Protein p53 / analysis*
  • Tumor Suppressor Protein p53 / genetics


  • Tumor Suppressor Protein p53