Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia

Arch Neurol. 1996 Jul;53(7):678-80. doi: 10.1001/archneur.1996.00550070116019.

Abstract

Objective: To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia.

Design and subjects: Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia.

Results: The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P < .02).

Conclusion: Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / metabolism*
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Brain / metabolism*
  • Brain / pathology
  • Choline / metabolism
  • Creatine / metabolism
  • Dementia, Vascular / diagnosis*
  • Dementia, Vascular / metabolism*
  • Diagnosis, Differential
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy*
  • Male
  • Middle Aged
  • Protons

Substances

  • Protons
  • Aspartic Acid
  • N-acetylaspartate
  • Creatine
  • Choline