3-Acetyl-4-aryl-5-oxo-2,7,7-trimethyl-1,4,5,6,7,8-hexahydro-quinoline derivatives and their calcium antagonistic activities

Abstract

Thirteen 3-acetyl-4-aryl-5-oxo-2,7,7-trimethyl-1,4,5,6,7,8- hexahydroquinoline derivatives (5a-m), one of which was synthesized before, have been prepared. The structures of the products 5b-m were characterized by IR,1H-NMR and elemental analysis. The calcium antagonistic activity of these compounds was studied in rabbit taenia coli precontracted with 1 mmol/l Ca+2.