Gastric non-Hodgkin lymphomas of mucosa-associated lymphoid tissue are not associated with more aggressive Helicobacter pylori strains as identified by CagA

Am J Clin Pathol. 1996 Nov;106(5):670-5. doi: 10.1093/ajcp/106.5.670.


Primary gastric non-Hodgkin lymphoma of mucosa-associated lymphoid tissue (MALT-NHL) is strongly related to Helicobacter pylori (H pylori) infection. CagA positive H pylori strains appear to be more aggressive, as reflected by a greater degree of gastric inflammation and higher levels of Il-8 production. Using a polymerase chain reaction-based assay, cagA status was determined in H pylori strains of 12 patients with gastric MALT-NHL, 38 patients with peptic ulcer disease, and 39 patients with non-ulcer dyspepsia. CagA-positive H pylori strains were significantly more frequent in peptic ulcer disease than in non-ulcer dyspepsia (Fisher's exact test p <0.001). An increased frequency of CagA-positive strains was not identified in gastric MALT-NHL compared to non-ulcer dyspepsia patients (Fisher's exact test P <.3). Therefore, it can be concluded that infection with more aggressive strains is associated with the development of peptic ulcer disease, but plays a minor role, if any, in the development of gastric MALT-NHL.

MeSH terms

  • Adult
  • Aged
  • Antigens, Bacterial / analysis
  • Antigens, Bacterial / genetics*
  • Bacterial Proteins / analysis
  • Bacterial Proteins / genetics*
  • Dyspepsia / microbiology
  • Dyspepsia / pathology
  • Female
  • Helicobacter Infections / pathology*
  • Helicobacter pylori / classification
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Lymphoma, B-Cell, Marginal Zone / microbiology
  • Lymphoma, B-Cell, Marginal Zone / pathology*
  • Male
  • Middle Aged
  • Peptic Ulcer / microbiology
  • Peptic Ulcer / pathology
  • Polymerase Chain Reaction / methods
  • Stomach Diseases / microbiology
  • Stomach Diseases / pathology*


  • Antigens, Bacterial
  • Bacterial Proteins
  • cagA protein, Helicobacter pylori