Multicentric reticulohistiocytosis

Clin Rheumatol. 1996 Jan;15(1):62-66. doi: 10.1007/BF02231688.


We describe a 42-year-old man with a five-year history of arthritis mutilans-like destructive joint changes and with a one-year history of nodules on the fingers, ears, oral mucosa, pharynx, larynx, vocal cords, some being ulcerated and haemorrhagic. He was diagnosed as having rheumatoid arthritis; however, biopsies from the nodules on the oral mucosa and ear revealed multicentric reticulohistiocytosis. The large nodule over the olecranon process, simulating a rheumatoid nodule but diagnosed as multicentric reticulohistiocytosis with biopsy; ulcerated and haemorrhagic nodules on the oral mucosa; and rapidly progressive joint destructions make our case interesting.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antirheumatic Agents / administration & dosage
  • Antirheumatic Agents / therapeutic use
  • Arthritis, Rheumatoid / diagnosis*
  • Arthritis, Rheumatoid / physiopathology
  • Azathioprine / administration & dosage
  • Azathioprine / therapeutic use
  • Biopsy, Needle
  • Diagnosis, Differential
  • Histiocytosis / diagnosis*
  • Histiocytosis / drug therapy
  • Histiocytosis / pathology
  • Histiocytosis / physiopathology
  • Humans
  • Male


  • Antirheumatic Agents
  • Azathioprine