Synthesis, antimicrobial and cytostatic activity of 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranosyl (-)-(S)-propanesulfinate

Farmaco. 1996 Aug-Sep;51(8-9):613-5.

Abstract

The synthesis of 1,2:5,6-di-O-isopropilidene-alpha-D-glucofuranosyl (-)-(S)-propanesulfinate 1 optically pure using diacetone-D-glucose as unique inducer of chirality and iPrEtN a base is described. Compound 1 was especially active against Gram positive bacteria. For the cytostatic activity, the ID50 value of compound 1 was inferior than those recommend by National Cancer Institute of USA for this type of compounds.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Glucose / analogs & derivatives*
  • Glucose / chemical synthesis
  • Glucose / pharmacology
  • Humans
  • Tumor Cells, Cultured

Substances

  • 1,2-5,6-di-O-isopropylideneglucofuranosyl propanesulfinate
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Glucose