Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 28 (9), 961-4

Alpha 1-antichymotrypsin

Affiliations
Review

Alpha 1-antichymotrypsin

N A Kalsheker. Int J Biochem Cell Biol.

Abstract

alpha 1-Antichymotrypsin, a member of the serine proteinase inhibitor (serpin) family, inhibits neutrophil proteinase cathepsin G and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes. It contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage and a major conformational change. Recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with Alzheimer's disease, and in vitro studies have shown that it enhances the rate of amyloid-fibril formation. These observations and recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of Alzheimer's disease.

Similar articles

See all similar articles

Cited by 26 articles

See all "Cited by" articles

MeSH terms

Substances

LinkOut - more resources

Feedback