Nerve growth factor NT-5 induce increased thermal sensitivity of cutaneous nociceptors in vitro

J Neurophysiol. 1996 Nov;76(5):3593-6. doi: 10.1152/jn.1996.76.5.3593.


1. Perfusion of the receptive field (RF) of C- or A delta-fiber nociceptors with nerve growth factor (NGF) in an in vitro preparation of the rat saphenous nerve with functionally attached skin induced a significant decrease in heat threshold without changing mechanical or cold sensitivity. 2. NGF-induced thermal sensitization was absent after saline perfusion and in skin taken from mast-cell depleted animals, hence confirming a role for mast cells in NGF-induced thermal hyperalgesia. 3. Neurotrophin-5 (NT-5) also induced a small but significant reduction in heat threshold without affecting mechanical sensitivity. It is speculated that NT-5 exerts its action either directly on the trkA receptor, as with NGF or alternatively through trkB receptors located on sympathetic efferents or on small diameter afferents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • In Vitro Techniques
  • Nerve Growth Factors / pharmacology*
  • Nociceptors / drug effects*
  • Rats
  • Rats, Wistar
  • Temperature


  • Nerve Growth Factors
  • neurotrophin 5