Mutagenicity studies on erythritol in bacterial reversion assay systems and in Chinese hamster fibroblast cells

Regul Toxicol Pharmacol. 1996 Oct;24(2 Pt 2):S261-3. doi: 10.1006/rtph.1996.0107.

Abstract

The sweetener erythritol tested negative in reverse mutation assays using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and the WP2 uvrA strain of Escherichia coli. Erythritol tested negative in chromosome aberration tests using the Chinese hamster fibroblast cell line CHL/IU.

MeSH terms

  • Animals
  • Cell Line
  • Chromosome Aberrations
  • Chromosomes / drug effects
  • Cricetinae
  • Cricetulus
  • Erythritol / toxicity*
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Fibroblasts / drug effects*
  • Fibroblasts / ultrastructure
  • Mutagenicity Tests
  • Mutagens / toxicity*
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Sweetening Agents / toxicity*

Substances

  • Mutagens
  • Sweetening Agents
  • Erythritol