Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

Nature. 1996 Nov 28;384(6607):327-33. doi: 10.1038/384327a0.


The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Cell Lineage
  • DNA-Binding Proteins / genetics*
  • Dwarfism, Pituitary / embryology
  • Dwarfism, Pituitary / genetics*
  • Female
  • Gene Expression
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / physiology
  • Hypothalamus / physiology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Pituitary Gland, Anterior / abnormalities
  • Pituitary Gland, Anterior / embryology*
  • Pituitary Gland, Anterior / physiology
  • Point Mutation
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Transcription Factor Pit-1
  • Transcription Factors / genetics*


  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Pit1 protein, mouse
  • Prophet of Pit-1 protein
  • Transcription Factor Pit-1
  • Transcription Factors

Associated data

  • GENBANK/U77946