Collagen sponge: theory and practice of medical applications

J Biomed Mater Res. 1977 Sep;11(5):721-41. doi: 10.1002/jbm.820110508.


Theoretical as well as practical-clinical applications of one form of collagen (collagen sponge) as a biodegradable material is reviewed. The role of porosity of the sponge and surface characteristics of the meshwork in relation to cell ingrowth are considered essential features of collagen sponge. Rate of resorption and antigenicity could be controlled by graded crosslinking of collagenous framework. Four basic examples of clinical use of collagen sponge are presented: as wound (burn) dressing material, as a matrix, for bone and cartilage repair, as an intravaginal contraceptive diaphragm, and as surgical tampons.

MeSH terms

  • Antigens
  • Bandages*
  • Biodegradation, Environmental
  • Bone and Bones / surgery*
  • Burns / therapy
  • Cartilage, Articular / surgery*
  • Collagen* / immunology
  • Contraceptive Devices, Female*
  • Female
  • Humans
  • Tampons, Surgical*


  • Antigens
  • Collagen