Transgenic models of neurodegenerative diseases

Curr Opin Neurobiol. 1996 Oct;6(5):651-60. doi: 10.1016/s0959-4388(96)80099-7.


Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinucleotide repeat diseases, result from a gain of deleterious properties. The disease-specific pathology in transgenic mice demonstrates the utility of these models in elucidating pathogenic mechanisms of the disease and in developing therapeutic strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / physiopathology*
  • Animals
  • Animals, Genetically Modified
  • Humans
  • Mice
  • Mice, Transgenic
  • Motor Neuron Disease / genetics
  • Motor Neuron Disease / pathology
  • Motor Neuron Disease / physiopathology*
  • Prion Diseases / pathology
  • Prion Diseases / physiopathology*
  • Spinocerebellar Degenerations / genetics*
  • Trinucleotide Repeats*