The In-Vitro Anti-Rickettsial Activity of Macrolides

J Antimicrob Chemother. 1996 Oct;38(4):727-31. doi: 10.1093/jac/38.4.727.

Abstract

The anti-rickettsial activity of azithromycin and clarithromycin was studied in Vero cells. The rate of rickettsial inhibition-growth caused by both macrolides was determined using rickettsial counts and ELISA. Both macrolides inhibited > 50% the growth of Rickettsia conorii and Rickettsia typhi at concentrations of 1.0 and 0.1 mg/L, respectively. The growth of Coxiella burnetii was inhibited to a rate of > or = 50% at the concentrations of 0.01 and 1.0 mg/L of azithromycin and clarithromycin, respectively.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Azithromycin / pharmacology*
  • Chlorocebus aethiops
  • Clarithromycin / pharmacology*
  • Colony Count, Microbial
  • Coxiella burnetii / drug effects*
  • Coxiella burnetii / growth & development
  • Microbial Sensitivity Tests
  • Rickettsia / drug effects*
  • Rickettsia / growth & development
  • Rickettsia typhi / drug effects*
  • Rickettsia typhi / growth & development
  • Vero Cells

Substances

  • Anti-Bacterial Agents
  • Azithromycin
  • Clarithromycin