Could schizophrenia be reasonably explained by Dohan's hypothesis on genetic interaction with a dietary peptide overload?

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Oct;20(7):1083-114. doi: 10.1016/s0278-5846(96)00099-1.


1. Dohan has proposed that schizophrenia is a genetic disposition which interacts with an overload of dietary proteins such as casein and gluten or gliadin. 2. A systematic attempt is made to see if this hypothesis is possible faced with aspects of schizophrenia that must be accounted for. 3. The authors conclusion is that it is possible, but more serious work in this field is urgently needed.

Publication types

  • Review

MeSH terms

  • Dietary Proteins / adverse effects*
  • Humans
  • Peptides / adverse effects*
  • Peptides / metabolism
  • Schizophrenia / etiology*
  • Schizophrenia / genetics*


  • Dietary Proteins
  • Peptides