No interaction between desipramine and bromperidol

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Oct;20(7):1265-71. doi: 10.1016/s0278-5846(96)00111-x.

Abstract

1. The authors studied the effects of coadministration of desipramine, which is a substrate of CYP2D6, on plasma concentrations of bromperidol and its reduced metabolite (reduced bromperidol). Clinical changes were also evaluated by the CGI and UKU. 2. The subjects were 13 schizophrenic inpatients receiving bromperidol 12.24 mg/day for 1.20 weeks. Desipramine 50 mg/day was coadministered for 1 week, and blood samplings and clinical ratings were performed before and after the coadministration. 3. Plasma concentrations of bromperidol and reduced bromperidol were measured by a HPLC method. 4. Desipramine coadministration did not affect plasma concentration of bromperidol (9.6 +/- 4.5 vs. 9.6 +/- 2.8 ng/ml) nor that of reduced bromperidol (2.8 +/- 2.5 vs. 2.8 +/- 2.1 ng/ml). 5. There was no significant change in the CGI scores nor UKU scores after desipramine coadministration. 6. The present study thus suggests that there is no interaction between desipramine and bromperidol.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antidepressive Agents, Tricyclic / adverse effects*
  • Antipsychotic Agents / blood
  • Antipsychotic Agents / pharmacokinetics*
  • Chromatography, High Pressure Liquid
  • Cytochrome P-450 CYP2D6 / metabolism
  • Desipramine / adverse effects*
  • Drug Interactions
  • Female
  • Haloperidol / analogs & derivatives*
  • Haloperidol / blood
  • Haloperidol / pharmacokinetics
  • Humans
  • Male
  • Oxidation-Reduction
  • Psychiatric Status Rating Scales
  • Schizophrenia / metabolism*
  • Schizophrenic Psychology

Substances

  • Antidepressive Agents, Tricyclic
  • Antipsychotic Agents
  • Cytochrome P-450 CYP2D6
  • Haloperidol
  • bromperidol
  • Desipramine