Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 31 (11), 1110-4

Disturbed Motilin and Cholecystokinin Release in the Irritable Bowel Syndrome

Affiliations

Disturbed Motilin and Cholecystokinin Release in the Irritable Bowel Syndrome

K Sjölund et al. Scand J Gastroenterol.

Abstract

Background: The irritable bowel syndrome (IBS) is associated with motor abnormalities in the small intestine and colon. Neuropeptides may have an important role in initiating and regulating the intestinal motility. Motilin has been proposed to initiate the peristaltic reflex in the small intestine and cholecystokinin the gastrocolic reflex.

Methods: In 18 patients with IBS and 11 healthy control subjects plasma motilin and cholecystokinin (CCK) concentrations were measured after intraluminal stimulation of water and a fat-rich meal.

Results: The IBS patients had reduced motilin secretion after both water intake and the fat meal. In contrast, the fat meal elicited an exaggerated and prolonged CCK release in the IBS patients.

Conclusions: Disturbed motilin and CCK release may partly be responsible for the intestinal dysmotility in the IBS patients.

Similar articles

See all similar articles

Cited by 19 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback