N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports

Can Fam Physician. 1996 Nov;42:2214-7.


Chronic fatigue syndrome is a heterogeneous condition with as proves effective treatment. I present two case reports in which N of 1 trials helped me make management decisions. High-dose vitamin B12 injections were ineffective in one case; nimodipine was very effective in the other case.

Publication types

  • Case Reports
  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Calcium Channel Blockers / therapeutic use*
  • Cross-Over Studies*
  • Decision Support Techniques*
  • Double-Blind Method
  • Fatigue Syndrome, Chronic / diagnosis
  • Fatigue Syndrome, Chronic / drug therapy*
  • Female
  • Humans
  • Middle Aged
  • Nimodipine / therapeutic use*
  • Vitamin B 12 / therapeutic use*


  • Calcium Channel Blockers
  • Nimodipine
  • Vitamin B 12