Macromolecular organization of basement membranes

Curr Opin Cell Biol. 1996 Oct;8(5):618-24. doi: 10.1016/s0955-0674(96)80102-5.


A considerable variety of basement membrane components, including in particular more than ten laminin isoforms and their novel alpha chains (alpha3, alpha4 and alpha5), has been characterized in recent studies. The functional properties of these components are increasingly being analyzed by recombinant technologies and by structural studies at atomic resolution, techniques which led to the elucidation of the nidogen-binding epitope on the laminin gamma1 chain. Novel insights into functions of basement membrane components have been obtained from gene-targeting experiments and studies of mutated genes identified in inherited disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Basement Membrane / metabolism
  • Binding Sites
  • Epitopes / chemistry
  • Humans
  • Laminin / chemistry*
  • Laminin / genetics
  • Laminin / immunology
  • Laminin / metabolism
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism
  • Receptors, Cell Surface
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / metabolism


  • Epitopes
  • Laminin
  • Membrane Proteins
  • Receptors, Cell Surface
  • Recombinant Proteins