Receptors for laminins during epithelial morphogenesis

Curr Opin Cell Biol. 1996 Oct;8(5):700-6. doi: 10.1016/s0955-0674(96)80112-8.

Abstract

Laminin-1 is expressed by many embryonic epithelial cell types. It binds to receptors on the epithelial cell surface. The integrin alpha6beta1 is a well known laminin-1 receptor that is expressed on many embryonic epithelial cells. More recently, dystroglycan was discovered as a high-affinity receptor for laminin-1 and laminin-2. It is expressed not only by muscle cells but also by embryonic epithelial cells. In embryonic epithelia, dystroglycan may act by binding to the E3 fragment of laminin-1. Integrins and the dystroglycan complex seems to be important for epithelial morphogenesis, but the relative roles of these two receptor systems for epithelial cells are still unclear.

Publication types

  • Review

MeSH terms

  • Animals
  • Basement Membrane / metabolism
  • Cells, Cultured
  • Epithelium / metabolism
  • Extracellular Matrix
  • Humans
  • Morphogenesis
  • Receptors, Laminin / metabolism*

Substances

  • Receptors, Laminin