The Dynamics of Cyclin Dependent Kinase Structure

Curr Opin Cell Biol. 1996 Dec;8(6):767-72. doi: 10.1016/s0955-0674(96)80076-7.

Abstract

In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition by the inhibitor p27, and binding by the CKS proteins.

Publication types

  • Review

MeSH terms

  • Cell Division / physiology
  • Cells / cytology
  • Cells / enzymology*
  • Cyclin-Dependent Kinases / chemistry*
  • Cyclin-Dependent Kinases / metabolism*
  • Phosphorylation
  • Protein Conformation

Substances

  • Cyclin-Dependent Kinases