The retinoblastoma protein pathway and the restriction point

Curr Opin Cell Biol. 1996 Dec;8(6):805-14. doi: 10.1016/s0955-0674(96)80081-0.


The emerging role of the retinoblastoma protein (pRb) as a major controller of the restriction point has been supported by recent discoveries, including pRb's ability to repress gene transcription by all three RNA polymerases, which suggests a link between DNA replication and cell growth. Convergent genetic and biochemical data provide new insights into the molecular events that are upstream of, at, and downstream of pRb phosphorylation, which is regulated by G1-phase cyclins and cyclin-dependent kinases (Cdks) and their inhibitors (CKIs). Major advances have also been made in our understanding of a key role of the pathway involving cyclin D, Cdks, CKIs, pRb and E2F both in commitment to traversing the cell cycle and in restraining oncogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle / physiology*
  • Cell Division / physiology
  • Cells / chemistry
  • Cells / cytology*
  • Retinoblastoma Protein / physiology*


  • Retinoblastoma Protein