Modulation of protein structure and function by asparagine-linked glycosylation

Chem Biol. 1996 Oct;3(10):803-12. doi: 10.1016/s1074-5521(96)90064-2.

Abstract

In eukaryotic cells, many enzymes are devoted to the construction of the complex glycan structures that decorate secreted and cell-surface proteins. Recent studies have begun to elucidate the effects of asparagine-linked glycosylation on protein folding and on the structure and function of mature glycoproteins.

Publication types

  • Review

MeSH terms

  • Asparagine / chemistry*
  • Glycopeptides / chemistry
  • Glycopeptides / metabolism
  • Glycoproteins / chemistry*
  • Glycoproteins / metabolism
  • Glycosylation
  • Protein Folding
  • Protein Structure, Secondary
  • Structure-Activity Relationship

Substances

  • Glycopeptides
  • Glycoproteins
  • Asparagine