Matrix metalloproteinases and the development of cancer

Chem Biol. 1996 Nov;3(11):895-904. doi: 10.1016/s1074-5521(96)90178-7.


Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multi-stage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Enzyme Activation
  • Humans
  • Metalloendopeptidases / genetics
  • Metalloendopeptidases / metabolism*
  • Multigene Family
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasms / enzymology*
  • Neoplasms / pathology


  • Metalloendopeptidases