The control of temporal and spatial organization during the Caulobacter cell cycle

Curr Opin Genet Dev. 1996 Oct;6(5):538-44. doi: 10.1016/s0959-437x(96)80081-5.


The Caulobacter cell cycle exhibits time-dependent expression of differentiation events. These include the morphological transition of a swarmer cell to a replication-competent stalked cell and the subsequent polarized distribution of specific gene products that results in an asymmetric predivisional cell. Cell division then yields a new swarmer cell and a stem-cell-like stalked cell. Two-component signal transduction proteins involved in cell cycle control and proteins required for cell division and flagellar biogenesis have been shown to be regulated temporally and spatially during the cell cycle. The mechanisms underlying this regulation include protein phosphorylation and proteolysis.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / metabolism
  • Caulobacter / cytology*
  • Caulobacter / genetics
  • Caulobacter / physiology*
  • Cell Cycle*
  • Cell Division
  • DNA Methylation
  • DNA Replication
  • DNA-Binding Proteins*
  • Endopeptidases / metabolism
  • Models, Biological
  • Phosphorylation
  • Transcription Factors*


  • Bacterial Proteins
  • CtrA protein, Caulobacter
  • DNA-Binding Proteins
  • Transcription Factors
  • Endopeptidases