Abstract
The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well as for proper meiotic chromosome segregation. DPY-26 was shown to mediate both processes through its association with chromosomes. In somatic cells, DPY-26 associates specifically with hermaphrodite X chromosomes to reduce their transcript levels. In germ cells, DPY-26 associates with all meiotic chromosomes to mediate its role in chromosome segregation. The X-specific localization of DPY-26 requires two dosage compensation proteins (DPY-27 and DPY-30) and two proteins that coordinately control both sex determination and dosage compensation (SDC-2 and SDC-3).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Caenorhabditis elegans / embryology
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / physiology*
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Caenorhabditis elegans Proteins*
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Carrier Proteins / physiology
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Cell Nucleus / chemistry
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Chromosomes / physiology*
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Disorders of Sex Development
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Dosage Compensation, Genetic*
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Embryonic Development
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Female
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Gene Expression
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Genes, Helminth
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Germ Cells / physiology
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Helminth Proteins / analysis
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Helminth Proteins / genetics
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Helminth Proteins / physiology*
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Male
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Meiosis*
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Molecular Sequence Data
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Mutation
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Nuclear Proteins / physiology
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X Chromosome / physiology
Substances
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Caenorhabditis elegans Proteins
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Carrier Proteins
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DPY-27 protein, C elegans
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Helminth Proteins
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Nuclear Proteins
Associated data
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GENBANK/U43562
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GENBANK/Z70680