Schizoid personality disorder after prenatal exposure to famine

Am J Psychiatry. 1996 Dec;153(12):1637-9. doi: 10.1176/ajp.153.12.1637.


Objective: The authors tested whether early prenatal exposure to famine was associated with schizophrenia spectrum personality disorder in addition to being associated with schizophrenia per se as shown in a previous study.

Method: The risk of schizoid personality disorder, as defined by ICD-6 to ICD-9, in men at age 18 years was compared in birth cohorts that were conceived at the height of the Dutch Hunger Winter famine and in unexposed birth cohorts of 1944-1946 in the famine region of Holland.

Results: The exposed cohort had a significantly greater risk (relative risk = 2.01) of schizoid personality disorder.

Conclusions: Prenatal nutritional deficiency was associated with a greater risk of schizoid personality disorder in men at age 18 years.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Cohort Studies
  • Confidence Intervals
  • Female
  • Humans
  • Male
  • Netherlands / epidemiology
  • Nutrition Disorders / epidemiology*
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Prevalence
  • Risk
  • Schizoid Personality Disorder / epidemiology*
  • Schizoid Personality Disorder / etiology
  • Sex Factors
  • Starvation / epidemiology*
  • Warfare