Dominance--one hundred and fifteen years after Mendel's paper

J Theor Biol. 1996 Oct 7;182(3):223-32. doi: 10.1006/jtbi.1996.0159.


In The Molecular Basis of Dominance, Kacser & Burns (1981) demonstrated that dominance in diploids and polyploids, and pleiotropy in all organisms, were biochemical phenomena; they were the consequences of the response of a metabolic system to a genetically specified change in the activity of any one enzyme within the system. Epistasis was similarly explicable when each of at least two enzyme activities suffered a change. The significance of this achievement by Kacser & Burns (1981) for biochemistry, genetics, molecular biology, medicine and bio-technology is best seen against the background of 115 years of attempts to explain the origins of dominance.

Publication types

  • Historical Article

MeSH terms

  • Animals
  • Genes, Dominant*
  • History, 19th Century
  • History, 20th Century
  • Metabolism / genetics*