Syndrome of inappropriate antidiuretic hormone secretion in neonates with pneumothorax or atelectasis

J Pediatr. 1977 Sep;91(3):459-63. doi: 10.1016/s0022-3476(77)81325-5.


Nine episodes of the syndrome of inappropriate antidiuretic hormone secretion occurred in five newborn infants following atelectasis or pneumothorax. All infants had pre-existing lung disease and were being treated with positive pressure ventilation. The mean interval between acute atelectasis or pneumothorax and the development of diagnostic hyponatremia, hypo-osmolal serum, hyperosmolal urine, and oliguria was 13.4 hours. Fluid restriction and removal of the triggering event resulted in resolution of the abnormalities within 1.5 to 4 days. Infants who develop atelectasis or pneumothorax should be evaluated for the subsequent occurrence of SIADH; the administration of a water load to them may result in dilutional hyponatremia, for which fluid restriction, not sodium infusion, is the proper therapy.

MeSH terms

  • Acute Disease
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases*
  • Osmolar Concentration
  • Pneumothorax / complications*
  • Pneumothorax / metabolism
  • Pulmonary Atelectasis / complications*
  • Pulmonary Atelectasis / metabolism
  • Sodium / metabolism
  • Syndrome
  • Vasopressins / metabolism*


  • Vasopressins
  • Sodium