Sclerotiamide: A New Member of the Paraherquamide Class With Potent Antiinsectan Activity From the Sclerotia of Aspergillus Sclerotiorum

J Nat Prod. 1996 Nov;59(11):1093-5. doi: 10.1021/np960607m.

Abstract

Sclerotiamide (1), a new fungal natural product related to the paraherquamides, was isolated by bioassay-guided fractionation of antiinsectan organic extracts from the sclerotia of Aspergillus sclerotiorum (NRRL 5167). The structure was determined primarily through 1H-NMR, 13C-NMR, HMQC, and HMBC experiments. Sclerotiamide causes significant mortality and unusual physiological effects in dietary assays against the corn earworm Helicoverpa zea.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aspergillus / chemistry*
  • Coleoptera / physiology*
  • Crystallography, X-Ray
  • Depression, Chemical
  • Drug Screening Assays, Antitumor
  • Feeding Behavior / drug effects
  • Indolizines / isolation & purification*
  • Indolizines / pharmacology
  • Insecticides / isolation & purification*
  • Insecticides / pharmacology
  • Larva
  • Magnetic Resonance Spectroscopy
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spiro Compounds / isolation & purification*
  • Spiro Compounds / pharmacology

Substances

  • Indolizines
  • Insecticides
  • Spiro Compounds
  • sclerotiamide