A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL

EMBO J. 1996 Nov 15;15(22):6166-71.


Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP3)-mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry. Here we report the amino acid sequence of a functional capacitative Ca2+ entry (CCE) channel that supports inward Ca2+ currents in the range of the cell resting potential. The expressed CCE channel opens upon depletion of Ca2+ stores by InsP3 or thapsigargin, suggesting that the newly identified channel supports the CCE coupled to InsP3 signalling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • Calcium / metabolism
  • Calcium Channels / chemistry*
  • Calmodulin-Binding Proteins
  • Cation Transport Proteins*
  • Cattle
  • Cells, Cultured
  • Cloning, Molecular
  • Drosophila
  • Drosophila Proteins*
  • Electrophoresis, Polyacrylamide Gel
  • Electrophysiology
  • Guanosine Triphosphate / pharmacology
  • Humans
  • Inositol Phosphates / pharmacology
  • Membrane Proteins
  • Molecular Sequence Data
  • Patch-Clamp Techniques
  • Sequence Analysis
  • Sequence Homology, Amino Acid
  • TRPC Cation Channels
  • Thapsigargin / pharmacology
  • Transient Receptor Potential Channels


  • Calcium Channels
  • Calmodulin-Binding Proteins
  • Cation Transport Proteins
  • Drosophila Proteins
  • Inositol Phosphates
  • Membrane Proteins
  • TRPC Cation Channels
  • TRPC4 ion channel
  • Transient Receptor Potential Channels
  • transient receptor potential cation channel, subfamily C, member 1
  • trpl protein, Drosophila
  • Thapsigargin
  • Guanosine Triphosphate
  • Calcium

Associated data

  • GENBANK/AJ224862
  • GENBANK/X99792