Incidence and significance of positive margins in radical prostatectomy specimens

Urol Clin North Am. 1996 Nov;23(4):651-63. doi: 10.1016/s0094-0143(05)70343-8.


This article discusses how the incidence of positive margins may be affected by patient selection, technical differences in performing radical prostatectomy, and processing and analysis of radical prostatectomy specimens. The various sites of positive margins and capsular incision are reviewed. Whether frozen sections should be used to assess margins is discussed, and the relation of margin positivity to progression following radical prostatectomy is evaluated.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Disease Progression
  • Follow-Up Studies
  • Frozen Sections
  • Humans
  • Male
  • Multivariate Analysis
  • Patient Selection
  • Prostate / pathology
  • Prostatectomy* / methods
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / surgery*
  • Specimen Handling