Abstract
The N-terminal amino-acid sequence of pig dipeptidyl-peptidase II (EC 3.4.14.2; DPP II) recently published (Huang, K., Takagaki, M., Kani, K. and Ohkubo, I. (1996) Biochim. Biophys. Acta 1290, 149-156) proves that the enzyme is homologous with lysosomal Pro-X carboxypeptidase (EC 3.4.16.2), and belongs to peptidase family S28 in clan SC. This is consistent with a number of biochemical similarities between these two prolyl bond-cleaving serine peptidases. DPP II is not related to granzymes, as was suggested by Huang et al.
MeSH terms
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Amino Acid Sequence
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Animals
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Carboxypeptidases / chemistry*
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Carboxypeptidases / metabolism
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Databases, Factual
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / chemistry*
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / metabolism
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Lysosomes / enzymology*
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Molecular Sequence Data
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Proline / metabolism
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Semen / enzymology
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Sequence Alignment
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Serine Endopeptidases / chemistry
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Serine Endopeptidases / metabolism
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Software
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Swine
Substances
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Proline
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Carboxypeptidases
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
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dipeptidyl peptidase II
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Serine Endopeptidases