Influence of magnesium deficiency on concentration of calcium in soft tissue of uremic rats

Ren Fail. 1996 Nov;18(6):847-54. doi: 10.3109/08860229609047711.


The influence of magnesium (Mg) deficiency on the concentration of calcium (Ca) in the aorta, heart, and kidney was evaluated in uremic rats. A total of 32 rats were randomly assigned to two groups: one group made uremic by the 5/6 nephrectomy method, and the other serving as sham-operated controls. Both groups were randomly assigned to two subgroups: one group given a Mg-deficient diet and the other fed a Mg-supplemented diet. After 12 weeks on the regimen, all animals were sacrificed. In Mg-supplemented uremic rats, the concentration of Ca in the aorta was higher than in Mg-supplemented control rats. The concentration of Ca in the aorta was further increased in Mg-deficient uremic rats. The concentrations of Ca in the heart and the kidney were also increased in Mg-deficient uremic rats, as compared with Mg-supplemented uremic rats. The concentration of Mg was decreased in the aorta and increased in the kidney of Mg-deficient rats. There was no significant influence of Mg deficiency on the concentration of phosphate in tissue. Results suggest that Mg deficiency in uremia may increase aortic calcification.

MeSH terms

  • Animals
  • Calcinosis / etiology*
  • Calcinosis / physiopathology
  • Calcium / analysis*
  • Calcium / blood
  • Culture Techniques
  • Diet
  • Disease Models, Animal
  • Magnesium / analysis*
  • Magnesium / blood
  • Magnesium Deficiency / complications*
  • Male
  • Phosphates / analysis*
  • Phosphates / blood
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Uremia


  • Phosphates
  • Magnesium
  • Calcium