On the value of menorrhagia as a predictor for coagulation disorders

Am J Hematol. 1996 Dec;53(4):234-8. doi: 10.1002/(SICI)1096-8652(199612)53:4<234::AID-AJH4>3.0.CO;2-Z.

Abstract

The value of menorrhagia as a predictor for mild bleeding disorders has been very little studied and the results are divergent. In the present study on 30 women with objectively verified menorrhagia, we found a significantly increased prevalence of von Willebrand's disease (20%). By keeping a strict sampling and laboratory routine, and by restricting sampling to cycle days 5-7, we also obtained a very low interindividual variation of von Willebrand factor and coagulation factor VIII. We conclude that menorrhagia is a valuable predictor for coagulation and platelet disorders, and that time of sampling is of importance. This should be considered in the investigation of menorrhagia, and can be a guideline in looking for mild bleeding disorders.

MeSH terms

  • Adult
  • Blood Cell Count
  • Blood Coagulation Disorders / complications
  • Blood Coagulation Disorders / diagnosis*
  • Blood Coagulation Disorders / epidemiology
  • Blood Coagulation Tests
  • Blood Proteins / analysis
  • Female
  • Hematocrit
  • Hemoglobins / analysis
  • Hemophilia A / complications
  • Hemophilia A / diagnosis
  • Hemophilia A / epidemiology
  • Humans
  • Menorrhagia / etiology*
  • Middle Aged
  • Prevalence
  • von Willebrand Diseases / complications
  • von Willebrand Diseases / diagnosis
  • von Willebrand Diseases / epidemiology

Substances

  • Blood Proteins
  • Hemoglobins