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. 1996 Jul;52(3):644-55.
doi: 10.1093/oxfordjournals.bmb.a011573.

Theoretical Neurobiology and Schizophrenia


Theoretical Neurobiology and Schizophrenia

K J Friston. Br Med Bull. .


This chapter addresses the idea that schizophrenia is a 'disconnection syndrome' from a theoretical and computational perspective. The distinction between anatomical and functional connectivity is reviewed and used as a framework to introduce empirical and computational evidence that schizophrenia involves, at some level, a disintegration of neuronal interactions. The chapter concludes with an example of computational neuroscience that relates observations on the dimensional complexity of neuronal dynamics in schizophrenia to the disconnection hypothesis.

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