Structure of the human retinoic acid receptor beta 1 gene

Biochim Biophys Acta. 1996 Nov 11;1309(1-2):1-4. doi: 10.1016/s0167-4781(96)00126-1.


We report the isolation and characterization of genomic sequences coding for the 5' end of human retinoic acid receptor beta 1, a fetal RAR isoform which is also expressed in small cell lung cancers. Primer extension analysis revealed a principal transcription start site with a secondary site 23 bp further upstream in both SCLC and fetal tissues. The sequences isolated were CpG-rich between -60 and the 3' end of the first exon but there were no features like a TATA-box or an Inr element. In several important aspects, the human RAR beta 1 differs from its mouse counterpart. The 5'-UTR is 823 bp long and is encoded by four exons (vs two in the mouse giving a 477 bp UTR). The 5' end of the mouse cDNA has been mapped to a 67 bp CT repeat which is absent in our sequences. We were also unable to find evidence for a human isoform RAR beta 3 which is widely expressed in mouse tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Carcinoma, Small Cell
  • Cloning, Molecular
  • CpG Islands / genetics
  • DNA, Complementary / genetics
  • Dinucleotide Repeats / genetics
  • Exons / genetics
  • Genes / genetics*
  • Humans
  • Lung Neoplasms
  • Mice
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • Receptors, Retinoic Acid / genetics*
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic / genetics
  • Tumor Cells, Cultured


  • DNA, Complementary
  • RNA, Messenger
  • Receptors, Retinoic Acid
  • retinoic acid receptor beta

Associated data

  • GENBANK/U49855
  • GENBANK/U52075
  • GENBANK/U52076