Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human

Biochim Biophys Acta. 1996 Nov 11;1309(1-2):37-41. doi: 10.1016/s0167-4781(96)00135-2.


cDNAs for rat mu-calpain large subunit and the calpain small subunit were cloned and sequenced. The large subunit encodes 713 amino-acid residues, which includes one deletion compared to that of human. The overall similarity is 89% to human mu-type, which is slightly lower than those compared between other types of calpain large subunits of rat and human (93-94%). On the other hand, the small subunit showed high conservation, being 94.0% identical to that of human. With these sequences, primary structures of all rat calpain subunits that have been considered to exist were completely elucidated.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Calpain / genetics*
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Humans
  • Molecular Sequence Data
  • Rats
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid*
  • Stomach


  • DNA, Complementary
  • Calpain

Associated data

  • GENBANK/U53858
  • GENBANK/U53859