Nonresponse to hepatitis B vaccines and the kinetics of anti-HBs production

J Med Virol. 1996 Dec;50(4):283-8. doi: 10.1002/(SICI)1096-9071(199612)50:4<283::AID-JMV1>3.0.CO;2-4.


No empirical data are available for the anti-HBs title required for protection against infection with the hepatitis B virus (HBV), but nonresponders to hepatitis B vaccines remain susceptible to infection. There may be an unexplained qualitative difference between hyporesponders and true nonresponders, but there is a clear association with HLA haplotypes. There is no evidence for silent infection with HBV in nonresponders.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic
  • Disease Susceptibility
  • Genes, MHC Class I
  • Genes, MHC Class II
  • Haplotypes
  • Hepatitis B / immunology*
  • Hepatitis B / prevention & control
  • Hepatitis B Antibodies / biosynthesis*
  • Hepatitis B Vaccines / immunology*
  • Humans
  • Kinetics
  • Vaccination*


  • Adjuvants, Immunologic
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines